Reaction Details |
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Target | Putative glycogen synthase kinase 3 alpha |
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Ligand | BDBM50322535 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | 2.8e+3± 2.0e+3 nM |
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Citation | Grütter, C; Simard, JR; Mayer-Wrangowski, SC; Schreier, PH; Pérez-Martín, J; Richters, A; Getlik, M; Gutbrod, O; Braun, CA; Beck, ME; Rauh, D Targeting GSK3 from Ustilago maydis: Type-II Kinase Inhibitors as Potential Antifungals. ACS Chem Biol7:1257-67 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Putative glycogen synthase kinase 3 alpha |
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Name: | Putative glycogen synthase kinase 3 alpha |
Synonyms: | Glycogen Synthase Kinase 3 (GSK3) |
Type: | Protein |
Mol. Mass.: | 45420.65 |
Organism: | Ustilago maydis (Smut fungus) |
Description: | A0A0D1CGS9 |
Residue: | 402 |
Sequence: | MSNAPLNGVKLNPLDDPNKVIKVLASDGKTGEQREIAYTNCKVIGNGSFGVVFQAKLVSQ
GSEPAEGSSKESDEVAIKKVLQDKRFKNRELQIMRIVKHPNVVDLKAFFYSNGDKKDEVF
LNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNL
LLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVM
AELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIRPHPFSKVFRP
RTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDELRTGEARMPNGRELPPLFNWTKEEL
SVRPDLISRLVPQHAEAELLSRGIDVHNFQPIPLESLKVTLD
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BDBM50322535 |
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n/a |
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Name | BDBM50322535 |
Synonyms: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | CHEMBL1171837 | PONATINIB | US10464902, Ponatinib | US9255107, AP24534 |
Type | Small organic molecule |
Emp. Form. | C29H27F3N6O |
Mol. Mass. | 532.5595 |
SMILES | CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1 |
Structure |
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