| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 6 |
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| Ligand | BDBM50056939 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization (FP) Assay |
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| IC50 | 1.25e+5± 2.0e+4 nM |
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| Citation |  Bannwarth, L; Goldberg, AB; Chen, C; Turk, BE Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening. Chem Biol19:875-82 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 6 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 6 |
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| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 6 | MAP kinase kinase 6 | MAP2K6 | MAPK/ERK kinase 6 | MAPKK 6 | MEK6 | MKK6 | MP2K6_HUMAN | Mitogen-activated protein kinase kinase 6 (MKK6) | PRKMK6 | SAPKK3 | SKK3 |
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| Type: | Protein |
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| Mol. Mass.: | 37494.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P52564 |
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| Residue: | 334 |
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| Sequence: | MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG
RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF
REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV
KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI
WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK
ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
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| BDBM50056939 |
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| n/a |
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| Name | BDBM50056939 |
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| Synonyms: | 4-Formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylic acid | CHEMBL176570 | NSC-92186 | Parellic acid, 3 | cid_23725 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14O8 |
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| Mol. Mass. | 358.299 |
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| SMILES | COc1cc(C(O)=O)c2Oc3c(C=O)c(O)cc(C)c3C(=O)Oc2c1C |
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| Structure | 
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