| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-2-microglobulin |
|---|
| Ligand | BDBM92395 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescence Assay |
|---|
| pH | 7.4±0 |
|---|
| Temperature | 310.15±0 K |
|---|
| IC50 | 9.8e+4± 1.2e+4 nM |
|---|
| Citation |  Giorgetti, S; Raimondi, S; Pagano, K; Relini, A; Bucciantini, M; Corazza, A; Fogolari, F; Codutti, L; Salmona, M; Mangione, P; Colombo, L; De Luigi, A; Porcari, R; Gliozzi, A; Stefani, M; Esposito, G; Bellotti, V; Stoppini, M Effect of tetracyclines on the dynamics of formation and destructuration of beta2-microglobulin amyloid fibrils. J Biol Chem286:2121-31 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Beta-2-microglobulin |
|---|
| Name: | Beta-2-microglobulin |
|---|
| Synonyms: | B2M | B2MG_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 13714.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P61769 |
|---|
| Residue: | 119 |
|---|
| Sequence: | MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL
KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
|
|
|
|---|
| BDBM92395 |
|---|
| n/a |
|---|
| Name | BDBM92395 |
|---|
| Synonyms: | Meclocycline |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H21ClN2O8 |
|---|
| Mol. Mass. | 476.864 |
|---|
| SMILES | CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(C(=O)c4c(O)ccc(Cl)c4C3=C)C(=O)[C@]2(O)C(=O)C(C(N)=O)C1=O |
|---|
| Structure | 
|
|---|
Search and Browse
