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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Beta-2-microglobulin | ||
| Ligand | BDBM55038 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Fluorescence Assay | ||
| pH | 7.4±0 | ||
| Temperature | 310.15±0 K | ||
| IC50 | 6.9e+4± 9e+3 nM | ||
| Citation |  Giorgetti, S; Raimondi, S; Pagano, K; Relini, A; Bucciantini, M; Corazza, A; Fogolari, F; Codutti, L; Salmona, M; Mangione, P; Colombo, L; De Luigi, A; Porcari, R; Gliozzi, A; Stefani, M; Esposito, G; Bellotti, V; Stoppini, M Effect of tetracyclines on the dynamics of formation and destructuration of beta2-microglobulin amyloid fibrils. J Biol Chem286:2121-31 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Beta-2-microglobulin | |||
| Name: | Beta-2-microglobulin | ||
| Synonyms: | B2M | B2MG_HUMAN | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 13714.40 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P61769 | ||
| Residue: | 119 | ||
| Sequence: |
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| BDBM55038 | |||
| n/a | |||
| Name | BDBM55038 | ||
| Synonyms: | (2E,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione;hydrochloride | (2E,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione;hydrochloride | (2E,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylidene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione;hydrochloride | (2E,4S,4aR,5S,5aR,12aS)-2-[azanyl(oxidanyl)methylidene]-4-(dimethylamino)-6-methylidene-5,10,11,12a-tetrakis(oxidanyl)-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione;hydrochloride | (4S,4aR,5S,5aR,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-3,12-diketo-6-methylene-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride | (4S,4aR,5S,5aS,12aS)-4-(dimethylamino)-5,10,12a-trihydroxy-1,3,11,12-tetraketo-6-methylene-4a,5,5a,11a-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride | MLS001049011 | Methacycline | SMR000387056 | cid_16196941 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H22N2O8 | ||
| Mol. Mass. | 442.4187 | ||
| SMILES | CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(C(=O)c4c(O)cccc4C3=C)C(=O)[C@]2(O)C(=O)C(C(N)=O)C1=O | ||
| Structure | 
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