| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [1027-1206,R1052K] |
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| Ligand | BDBM92407 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| pH | 8±0 |
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| Ki | 0.53±0.05 nM |
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| KOFF | 4.4E-4 s-1 |
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| KON | 8.5E5 M-1s-1 |
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| Citation |  Lemke, CT; Goudreau, N; Zhao, S; Hucke, O; Thibeault, D; Llinás-Brunet, M; White, PW Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335. J Biol Chem286:11434-43 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Genome polyprotein [1027-1206,R1052K] |
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| Name: | Genome polyprotein [1027-1206,R1052K] |
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| Synonyms: | HCV NS3 Proteinase | NS3-NS4A Protein | POLG_HCVCO |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 18947.03 |
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| Organism: | Hepatitis C virus |
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| Description: | HCV (BK strain) NS3 protein region from amino acid 1 to 180, harboring a C-terminal poly Lys solubilization motif (ASKKKK). |
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| Residue: | 180 |
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| Sequence: | APITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAG
SKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRG
DSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMR
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| BDBM92407 |
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| n/a |
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| Name | BDBM92407 |
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| Synonyms: | BI201335 |
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| Type | Peptide |
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| Emp. Form. | C40H49BrN6O9S |
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| Mol. Mass. | 869.821 |
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| SMILES | COc1ccc2c(O[C@@H]3CC(N(C3)C(=O)[C@@H](NC(=O)OC3CCCC3)C(C)(C)C)C(=O)N[C@@]3(CC3C=C)C(O)=O)cc(nc2c1Br)-c1csc(NC(=O)C(C)C)n1 |r| |
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| Structure | 
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