| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional protein GlmU |
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| Ligand | BDBM92474 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.35±0 |
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| IC50 | 23±n/a nM |
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| Citation |  Buurman, ET; Andrews, B; Gao, N; Hu, J; Keating, TA; Lahiri, S; Otterbein, LR; Patten, AD; Stokes, SS; Shapiro, AB In vitro validation of acetyltransferase activity of GlmU as an antibacterial target in Haemophilus influenzae. J Biol Chem286:40734-42 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Bifunctional protein GlmU |
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| Name: | Bifunctional protein GlmU |
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| Synonyms: | Bifunctional protein (GlmU) | GLMU_HAEIN | Glucosamine-1-phosphate N-acetyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | glmU |
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| Type: | Enzyme |
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| Mol. Mass.: | 49287.19 |
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| Organism: | Haemophilus influenzae |
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| Description: | P43889 |
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| Residue: | 456 |
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| Sequence: | MTKKALSAVILAAGKGTRMYSDLPKVLHTIAGKPMVKHVIDTAHQLGSENIHLIYGHGGD
LMRTHLANEQVNWVLQTEQLGTAHAVQQAAPFFKDNENIVVLYGDAPLITKETLEKLIEA
KPENGIALLTVNLDNPTGYGRIIRENGNVVAIVEQKDANAEQLNIKEVNTGVMVSDGASF
KKWLARVGNNNAQGEYYLTDLIALANQDNCQVVAVQATDVMEVEGANNRLQLAALERYFQ
NKQASKLLLEGVMIYDPARFDLRGTLEHGKDVEIDVNVIIEGNVKLGDRVKIGTGCVLKN
VVIGNDVEIKPYSVLEDSIVGEKAAIGPFSRLRPGAELAAETHVGNFVEIKKSTVGKGSK
VNHLTYVGDSEIGSNCNIGAGVITCNYDGANKFKTIIGDDVFVGSDTQLVAPVKVANGAT
IGAGTTITRDVGENELVITRVAQRHIQGWQRPIKKK
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| BDBM92474 |
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| n/a |
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| Name | BDBM92474 |
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| Synonyms: | Sulfonamide, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22N2O8S |
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| Mol. Mass. | 498.505 |
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| SMILES | COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)N1c2ccccc2Oc2ccccc12 |
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| Structure | 
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