| Reaction Details |
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 | Report a problem with these data |
| Target | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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| Ligand | BDBM92776 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CYP24A1Inhibition Assay |
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| Ki | 90± 10 nM |
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| Citation |  Zhu, J; Barycki, R; Chiellini, G; Deluca, HF Screening of selective inhibitors of 1a,25-dihydroxyvitamin D3 24-hydroxylase using recombinant human enzyme expressed in Escherichia coli. Biochemistry49:10403-11 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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| Name: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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| Synonyms: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | CP24A_HUMAN | CYP24 | CYP24A1 | Cytochrome P450 24A1 |
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| Type: | Protein |
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| Mol. Mass.: | 58889.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07973 |
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| Residue: | 514 |
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| Sequence: | MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN
EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM
AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD
FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL
PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ
VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV
RKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
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| BDBM92776 |
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| n/a |
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| Name | BDBM92776 |
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| Synonyms: | 24COOH-25(OH)D3 |
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| Type | Small molecule |
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| Emp. Form. | C24H36O3 |
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| Mol. Mass. | 372.5408 |
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| SMILES | C[C@@H](CCC(O)=O)C1CCC2\C(CCC[C@]12C)=C\C=C1\C[C@H](O)CCC1=C |r| |
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| Structure | 
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