Reaction Details |
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Target | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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Ligand | BDBM92780 |
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Substrate/Competitor | n/a |
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Meas. Tech. | CYP24A1Inhibition Assay |
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Ki | 21± 6 nM |
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Citation | Zhu, J; Barycki, R; Chiellini, G; Deluca, HF Screening of selective inhibitors of 1a,25-dihydroxyvitamin D3 24-hydroxylase using recombinant human enzyme expressed in Escherichia coli. Biochemistry49:10403-11 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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Name: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
Synonyms: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | CP24A_HUMAN | CYP24 | CYP24A1 | Cytochrome P450 24A1 |
Type: | Protein |
Mol. Mass.: | 58889.66 |
Organism: | Homo sapiens (Human) |
Description: | Q07973 |
Residue: | 514 |
Sequence: | MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN
EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM
AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD
FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL
PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ
VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV
RKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
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BDBM92780 |
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n/a |
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Name | BDBM92780 |
Synonyms: | VIMI |
Type | Small molecule |
Emp. Form. | C25H36N2O2 |
Mol. Mass. | 396.5655 |
SMILES | C[C@@H](Cn1ccnc1)C1CCC2\C(CCC[C@]12C)=C\C=C1\C[C@H](O)C(=C)[C@H](O)C1 |r| |
Structure |
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