| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 3 |
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| Ligand | BDBM93224 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| IC50 | 2.1e+4±n/a nM |
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| Citation |  Urich, R; Wishart, G; Kiczun, M; Richters, A; Tidten-Luksch, N; Rauh, D; Sherborne, B; Wyatt, PG; Brenk, R De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments. ACS Chem Biol8:1044-52 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-activated protein kinase 3 |
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| Name: | MAP kinase-activated protein kinase 3 |
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| Synonyms: | 3pK | Chromosome 3p kinase | MAP kinase-activated protein kinase 3 (MAPKAP-K3) | MAPK-Activated Protein Kinase 3 (MK3) | MAPK-activated protein kinase 3 | MAPK3_HUMAN | MAPKAP kinase 3 | MAPKAPK-3 | MAPKAPK3 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 42991.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant MAPKAPK3 was phosphorylated by incubation with active p38alpha before assays. |
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| Residue: | 382 |
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| Sequence: | MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
LLNKRRKKQAGSSSASQGCNNQ
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| BDBM93224 |
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| n/a |
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| Name | BDBM93224 |
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| Synonyms: | Kinase inhibitor, A1 |
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| Type | Small molecule |
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| Emp. Form. | C14H18N4O2 |
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| Mol. Mass. | 274.3183 |
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| SMILES | CC1CN(CC(C)O1)c1nc2ccccn2c(=O)c1N |
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| Structure | 
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