| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Sgk1 |
|---|
| Ligand | BDBM93227 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Assay |
|---|
| IC50 | 1.10e+5±n/a nM |
|---|
| Citation |  Urich, R; Wishart, G; Kiczun, M; Richters, A; Tidten-Luksch, N; Rauh, D; Sherborne, B; Wyatt, PG; Brenk, R De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments. ACS Chem Biol8:1044-52 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Sgk1 |
|---|
| Name: | Serine/threonine-protein kinase Sgk1 |
|---|
| Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) |
|---|
| Type: | Other Protein Type |
|---|
| Mol. Mass.: | 48954.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. |
|---|
| Residue: | 431 |
|---|
| Sequence: | MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
|
|
|
|---|
| BDBM93227 |
|---|
| n/a |
|---|
| Name | BDBM93227 |
|---|
| Synonyms: | Kinase inhibitor, C2 |
|---|
| Type | Small molecule |
|---|
| Emp. Form. | C14H12N2O3S |
|---|
| Mol. Mass. | 288.322 |
|---|
| SMILES | COc1ccc(cc1OC)-c1cc2c(nc[nH]c2=O)s1 |
|---|
| Structure | 
|
|---|
Search and Browse
