Reaction Details | |||
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Target | G_PROTEIN_RECEP_F1_2 domain-containing protein | ||
Ligand | BDBM405271 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Activity Assay | ||
IC50 | 0.270±n/a nM | ||
Citation | Lu, H; Sun, P; Gui, B; Dong, Q Pyrazolopyrimidone or Pyrrolotriazone derivatives, method of preparing same, and pharmaceutical applications thereof US Patent US10344034 Publication Date 7/9/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
G_PROTEIN_RECEP_F1_2 domain-containing protein | |||
Name: | G_PROTEIN_RECEP_F1_2 domain-containing protein | ||
Synonyms: | GNRHR | G_PROTEIN_RECEP_F1_2 domain-containing protein | Gonadotropin releasing hormone receptor (GNRHR) | ||
Type: | Protein | ||
Mol. Mass.: | 38055.85 | ||
Organism: | Oryctolagus cuniculus (Rabbit) | ||
Description: | G1TCS6 | ||
Residue: | 328 | ||
Sequence: |
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BDBM405271 | |||
n/a | |||
Name | BDBM405271 | ||
Synonyms: | 1-(4-(3-((dimethylamino)methyl)-5-(2-fluoro-3-methoxyphenyl)-7-(2-fluoro-6-(trifluoromethyl)benzyl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)phenyl)-3-methylurea | US10344034, Example 8 | US10633388, Example 8 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H28F5N7O4 | ||
Mol. Mass. | 657.5905 | ||
SMILES | CNC(=O)Nc1ccc(cc1)-n1nc2n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(-c3cccc(OC)c3F)c(=O)c2c1CN(C)C |(-9.14,-1.9,;-8.37,-.56,;-6.83,-.56,;-6.06,-1.9,;-6.06,.77,;-4.52,.77,;-3.75,-.56,;-2.21,-.56,;-1.44,.77,;-2.21,2.1,;-3.75,2.1,;.1,.77,;1.01,-.48,;2.47,,;3.8,-.77,;3.8,-2.31,;5.14,-3.08,;6.47,-2.31,;7.81,-1.54,;7.81,-3.08,;7.81,-4.62,;6.47,-5.39,;5.14,-4.62,;3.8,-5.39,;2.47,-4.62,;3.8,-6.93,;5.14,-6.16,;5.14,,;6.47,-.77,;5.14,1.54,;6.47,2.31,;7.81,1.54,;9.14,2.31,;9.14,3.85,;7.81,4.62,;7.81,6.16,;6.47,6.93,;6.47,3.85,;5.14,4.62,;3.8,2.31,;3.8,3.85,;2.47,1.54,;1.01,2.02,;.61,3.5,;-.88,3.9,;-1.28,5.39,;-1.97,2.81,)| | ||
Structure |