| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
|---|
| Ligand | BDBM99037 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| IC50 | 2.9±n/a nM |
|---|
| Citation |  Allen, JR; Horne, DB; Harrington, EH; Kaller, MR; Monenschein, H; Nguyen, TT; Reichelt, A; Rzasa, RM Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors US Patent US8497265 Publication Date 7/30/2013 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
|---|
| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
|---|
| Synonyms: | PDE10_RAT | Pde10a | Phosphodiesterase 10 | Phosphodiesterase 10A (PDE10A2) | Phosphodiesterase Type 10 (PDE10A) | Rat recombinant PDE10a (rPDE10a) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 90160.88 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | PDE10A was generated from the full-length recombinant rat clone transfected into Sf9 cells. |
|---|
| Residue: | 794 |
|---|
| Sequence: | MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK
NNKAEDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKAD
GFALYFLGECNNSLCVFTPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGD
ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA
SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF
QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP
RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL
ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMHFNLPARICRDIELFHFDIG
PFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI
LQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV
SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQS
HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRD
EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPAT
SKSTSEKPTRKVDD
|
|
|
|---|
| BDBM99037 |
|---|
| n/a |
|---|
| Name | BDBM99037 |
|---|
| Synonyms: | US8497265, 677 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H27N5O2 |
|---|
| Mol. Mass. | 453.5356 |
|---|
| SMILES | CC(=O)N1CCC(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
