| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 2 |
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| Ligand | BDBM100346 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Calcium Fluorescence Assay (FLIPR) |
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| IC50 | 3.23e+3±n/a nM |
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| Citation |  Hachtel, S; Dedio, J; DeFossa, E; Grueneberg, S; Heitsch, H; Bock, W; Chen, C; Kosley, R; Kung, C; Patek, M; Sher, R; Shimshock, S; Weichsel, A CXCR2 inhibitors US Patent US8501981 Publication Date 8/6/2013 |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 2 |
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| Name: | C-X-C chemokine receptor type 2 |
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| Synonyms: | C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B |
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| Type: | Protein |
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| Mol. Mass.: | 40767.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25025 |
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| Residue: | 360 |
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| Sequence: | MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
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| BDBM100346 |
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| n/a |
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| Name | BDBM100346 |
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| Synonyms: | US8501981, 105 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22FNO5 |
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| Mol. Mass. | 423.4336 |
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| SMILES | OC(=O)C1(CCC1)NC(=O)c1ccc2ccccc2c1OCCOc1ccc(F)cc1 |
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| Structure | 
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