| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM280601 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Competitive Activity-Based Protein Profiling |
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| IC50 | <100±n/a nM |
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| Citation |  Cisar, JS; Grice, CA; Jones, TK; Weber, OD; Buzard, DJ; Shaghafi, MB Spirocycle compounds and methods of making and using same US Patent US10030020 Publication Date 7/24/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL) |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33391.67 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells. |
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| Residue: | 303 |
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| Sequence: | MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLG
HSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRID
SSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAG
CPP
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|
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| BDBM280601 |
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| n/a |
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| Name | BDBM280601 |
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| Synonyms: | US10030020, Example 146 | US10781211, Example 146 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29F6N3O4S |
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| Mol. Mass. | 557.549 |
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| SMILES | CS(=O)(=O)N1CCc2cccc(CN3CCCC33CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)c2C1 |
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| Structure | 
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