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TargetSerine/threonine-protein kinase PAK 4
LigandBDBM101485
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
Ki 38±n/a nM
EC50 78±0 nM
Citation Zhang, JGuo, CBouzida, DDong, LLi, HMarakovits, JTYang, AHong, Y Pyrrolopyrazoles, potent kinase inhibitors US Patent US8530652 Publication Date 9/10/2013
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase PAK 4
Name:Serine/threonine-protein kinase PAK 4
Synonyms:KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4)
Type:Protein
Mol. Mass.:64098.01
Organism:Homo sapiens (Human)
Description:O96013
Residue:591
Sequence:
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
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  Blast E-value cutoff:
BDBM101485
n/a
NameBDBM101485
Synonyms:US8524710, 62 | US8530652, 12 | US8530652, 56
TypeSmall organic molecule
Emp. Form.C25H24ClN7O
Mol. Mass.473.957
SMILESCC1(C)N(Cc2c(Nc3nc(Cl)nc4ccccc34)[nH]nc12)C(=O)NC1CC1c1ccccc1
Structure
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