Compile Data Set for Download or QSAR

Found 120 hits with Last Name = 'bouzida' and Initial = 'd'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101546 (US8530494, 211 | US8530652, 125 | US8530652, 73) Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C25H29N7O2S/c1-15-26-18-11-12-35-20(18)23(27-15)28-22-17-13-32(25(2,3)21(17)29-30-22)24(33)34-19(14-31(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H2,26,27,28,29,30)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.60	n/a	n/a	n/a	<3.90	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101542 (US8530494, 207 | US8530652, 121 | US8530652, 69) Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3nc(C)nc4sccc34)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C25H29N7O2S/c1-15-26-21(17-11-12-35-23(17)27-15)28-22-18-13-32(25(2,3)20(18)29-30-22)24(33)34-19(14-31(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H2,26,27,28,29,30)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.90	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50389112 (CHEMBL2064556) Show SMILES CN(C)C[C@@H](NC(=O)c1ccc2[nH]nc(-c3nc4ccc(NCc5ccc(cc5)-c5ccccn5)cc4[nH]3)c2c1)c1ccccc1 |r| Show InChI InChI=1S/C37H34N8O/c1-45(2)23-34(25-8-4-3-5-9-25)42-37(46)27-15-17-31-29(20-27)35(44-43-31)36-40-32-18-16-28(21-33(32)41-36)39-22-24-11-13-26(14-12-24)30-10-6-7-19-38-30/h3-21,34,39H,22-23H2,1-2H3,(H,40,41)(H,42,46)(H,43,44)/t34-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PAK4				J Med Chem 55: 4728-39 (2012) Article DOI: 10.1021/jm300204j BindingDB Entry DOI: 10.7270/Q2BZ673W
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101479 (US8524710, 56 | US8530652, 50 | US8530652, 6) Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(Cl)nc4ccsc34)n[nH]c2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C24H27ClN8OS/c1-24(2)19-15(20(31-30-19)28-21-18-16(10-11-35-18)26-22(25)29-21)12-33(24)23(34)27-17(13-32(3)4)14-8-6-5-7-9-14/h5-11,17H,12-13H2,1-4H3,(H,27,34)(H2,26,28,29,30,31)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.80	n/a	n/a	n/a	0.940	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101537 (US8530494, 204 | US8530652, 115 | US8530652, 64) Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(nc4ccccc34)C#N)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C27H29N9O/c1-27(2)23-19(15-36(27)26(37)30-21(16-35(3)4)17-10-6-5-7-11-17)25(34-33-23)32-24-18-12-8-9-13-20(18)29-22(14-28)31-24/h5-13,21H,15-16H2,1-4H3,(H,30,37)(H2,29,31,32,33,34)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	<3.90	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50389111 (CHEMBL2064555) Show SMILES CN(C)C[C@@H](NC(=O)c1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1)c1ccccc1 |r| Show InChI InChI=1S/C25H24N6O/c1-31(2)15-22(16-8-4-3-5-9-16)28-25(32)17-12-13-19-18(14-17)23(30-29-19)24-26-20-10-6-7-11-21(20)27-24/h3-14,22H,15H2,1-2H3,(H,26,27)(H,28,32)(H,29,30)/t22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				J Med Chem 55: 4728-39 (2012) Article DOI: 10.1021/jm300204j BindingDB Entry DOI: 10.7270/Q2BZ673W
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM4838 (US8524710, 83 | US8530494, 13 | US8530652, 52) Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)c2sccc2n1 |r| Show InChI InChI=1S/C24H25N7OS/c1-13-25-17-9-10-33-19(17)22(26-13)28-21-16-12-31(24(2,3)20(16)29-30-21)23(32)27-18-11-15(18)14-7-5-4-6-8-14/h4-10,15,18H,11-12H2,1-3H3,(H,27,32)(H2,25,26,28,29,30)/t15-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3.5	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM4838 (US8524710, 83 | US8530494, 13 | US8530652, 52) Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)c2sccc2n1 |r| Show InChI InChI=1S/C24H25N7OS/c1-13-25-17-9-10-33-19(17)22(26-13)28-21-16-12-31(24(2,3)20(16)29-30-21)23(32)27-18-11-15(18)14-7-5-4-6-8-14/h4-10,15,18H,11-12H2,1-3H3,(H,27,32)(H2,25,26,28,29,30)/t15-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3.5	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101547 (US8530494, 212 | US8530652, 126 | US8530652, 74) Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3nc(nc4ccccc34)C#N)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C27H28N8O2/c1-27(2)23-19(15-35(27)26(36)37-21(16-34(3)4)17-10-6-5-7-11-17)25(33-32-23)31-24-18-12-8-9-13-20(18)29-22(14-28)30-24/h5-13,21H,15-16H2,1-4H3,(H2,29,30,31,32,33)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3.60	n/a	n/a	n/a	<3.90	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101544 (US8530494, 105 | US8530652, 123 | US8530652, 71) Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ncnc4sc(C)cc34)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C25H29N7O2S/c1-15-11-17-21(26-14-27-23(17)35-15)28-22-18-12-32(25(2,3)20(18)29-30-22)24(33)34-19(13-31(4)5)16-9-7-6-8-10-16/h6-11,14,19H,12-13H2,1-5H3,(H2,26,27,28,29,30)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101548 (US8530494, 108 | US8530652, 127 | US8530652, 75) Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ncnc4sccc34)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C24H27N7O2S/c1-24(2)19-17(21(29-28-19)27-20-16-10-11-34-22(16)26-14-25-20)12-31(24)23(32)33-18(13-30(3)4)15-8-6-5-7-9-15/h5-11,14,18H,12-13H2,1-4H3,(H2,25,26,27,28,29)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5.20	n/a	n/a	n/a	<3.90	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50389111 (CHEMBL2064555) Show SMILES CN(C)C[C@@H](NC(=O)c1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1)c1ccccc1 |r| Show InChI InChI=1S/C25H24N6O/c1-31(2)15-22(16-8-4-3-5-9-16)28-25(32)17-12-13-19-18(14-17)23(30-29-19)24-26-20-10-6-7-11-21(20)27-24/h3-14,22H,15H2,1-2H3,(H,26,27)(H,28,32)(H,29,30)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PAK4				J Med Chem 55: 4728-39 (2012) Article DOI: 10.1021/jm300204j BindingDB Entry DOI: 10.7270/Q2BZ673W
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101541 (US8530494, 104 | US8530652, 120 | US8530652, 68) Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ncnc4ccsc34)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C24H27N7O2S/c1-24(2)20-16(21(29-28-20)27-22-19-17(10-11-34-19)25-14-26-22)12-31(24)23(32)33-18(13-30(3)4)15-8-6-5-7-9-15/h5-11,14,18H,12-13H2,1-4H3,(H2,25,26,27,28,29)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	6.70	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101504 (US8524699, 91 | US8524710, 82 | US8530652, 31) Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)c2ccsc2n1 |r| Show InChI InChI=1S/C24H25N7OS/c1-13-25-20(15-9-10-33-22(15)26-13)28-21-17-12-31(24(2,3)19(17)29-30-21)23(32)27-18-11-16(18)14-7-5-4-6-8-14/h4-10,16,18H,11-12H2,1-3H3,(H,27,32)(H2,25,26,28,29,30)/t16-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	7.20	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101549 (US8530494, 109 | US8530652, 128 | US8530652, 76) Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ccnc(n3)C(F)(F)F)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C23H26F3N7O2/c1-22(2)18-15(19(31-30-18)28-17-10-11-27-20(29-17)23(24,25)26)12-33(22)21(34)35-16(13-32(3)4)14-8-6-5-7-9-14/h5-11,16H,12-13H2,1-4H3,(H2,27,28,29,30,31)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	8.30	n/a	n/a	n/a	<3.90	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101543 (US8530494, 206 | US8530652, 122 | US8530652, 70) Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ccnc(n3)C#N)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C23H26N8O2/c1-23(2)20-16(21(29-28-20)27-18-10-11-25-19(12-24)26-18)13-31(23)22(32)33-17(14-30(3)4)15-8-6-5-7-9-15/h5-11,17H,13-14H2,1-4H3,(H2,25,26,27,28,29)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	8.80	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101476 (US8524710, 53 | US8530652, 3 | US8530652, 47) Show SMILES CN1CCN([C@@H](Cc2ccccc2)C1)C(=O)N1Cc2c(Nc3nc(Cl)nc4ccsc34)[nH]nc2C1(C)C |r| Show InChI InChI=1S/C26H29ClN8OS/c1-26(2)21-18(22(32-31-21)29-23-20-19(9-12-37-20)28-24(27)30-23)15-35(26)25(36)34-11-10-33(3)14-17(34)13-16-7-5-4-6-8-16/h4-9,12,17H,10-11,13-15H2,1-3H3,(H2,28,29,30,31,32)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	11	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50389116 (CHEMBL2064561) Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)c3ccccc3)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C25H29N5O3/c1-25(2)21-19(22(28-27-21)26-23(31)18-13-9-6-10-14-18)15-30(25)24(32)33-20(16-29(3)4)17-11-7-5-8-12-17/h5-14,20H,15-16H2,1-4H3,(H2,26,27,28,31)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PAK4				J Med Chem 55: 4728-39 (2012) Article DOI: 10.1021/jm300204j BindingDB Entry DOI: 10.7270/Q2BZ673W
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50389117 (CHEMBL2064562) Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)c3ccc(F)cc3)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C25H28FN5O3/c1-25(2)21-19(22(29-28-21)27-23(32)17-10-12-18(26)13-11-17)14-31(25)24(33)34-20(15-30(3)4)16-8-6-5-7-9-16/h5-13,20H,14-15H2,1-4H3,(H2,27,28,29,32)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PAK4				J Med Chem 55: 4728-39 (2012) Article DOI: 10.1021/jm300204j BindingDB Entry DOI: 10.7270/Q2BZ673W
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101475 (US8524710, 52 | US8530652, 2 | US8530652, 46) Show SMILES CC1(C)N(Cc2c(Nc3nc(Cl)nc4ccsc34)[nH]nc12)C(=O)NC1CC1c1ccccc1 Show InChI InChI=1S/C23H22ClN7OS/c1-23(2)18-14(11-31(23)22(32)26-16-10-13(16)12-6-4-3-5-7-12)19(30-29-18)27-20-17-15(8-9-33-17)25-21(24)28-20/h3-9,13,16H,10-11H2,1-2H3,(H,26,32)(H2,25,27,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	14	n/a	n/a	n/a	36	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101530 (US8530494, 29 | US8530494, 7 | US8530652, 57) Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ncnc4n(C)cnc34)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C24H30N10O/c1-24(2)19-16(20(31-30-19)29-21-18-22(26-13-25-21)33(5)14-27-18)11-34(24)23(35)28-17(12-32(3)4)15-9-7-6-8-10-15/h6-10,13-14,17H,11-12H2,1-5H3,(H,28,35)(H2,25,26,29,30,31)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	14	n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101535 (US8530494, 104 | US8530652, 113 | US8530652, 62) Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ncnc4sc(C)cc34)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C25H30N8OS/c1-15-11-17-21(26-14-27-23(17)35-15)29-22-18-12-33(25(2,3)20(18)30-31-22)24(34)28-19(13-32(4)5)16-9-7-6-8-10-16/h6-11,14,19H,12-13H2,1-5H3,(H,28,34)(H2,26,27,29,30,31)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101545 (US8530494, 107 | US8530652, 124 | US8530652, 72) Show SMILES CCOc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)O[C@H](CN(C)C)c2ccccc2)C3(C)C)n1 |r| Show InChI InChI=1S/C24H30FN7O3/c1-6-34-22-26-12-17(25)21(28-22)27-20-16-13-32(24(2,3)19(16)29-30-20)23(33)35-18(14-31(4)5)15-10-8-7-9-11-15/h7-12,18H,6,13-14H2,1-5H3,(H2,26,27,28,29,30)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	16	n/a	n/a	n/a	4.40	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101515 (US8524699, 26 | US8530652, 42 | US8530670, 31) Show SMILES CC1(C)N(Cc2c(Nc3ncnc4sccc34)[nH]nc12)C(=O)N[C@@H]1C[C@H]1c1ccccc1 |r| Show InChI InChI=1S/C23H23N7OS/c1-23(2)18-16(20(29-28-18)27-19-14-8-9-32-21(14)25-12-24-19)11-30(23)22(31)26-17-10-15(17)13-6-4-3-5-7-13/h3-9,12,15,17H,10-11H2,1-2H3,(H,26,31)(H2,24,25,27,28,29)/t15-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	16	n/a	n/a	n/a	340	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101524 (US8530652, 51 | US8530652, 96) Show SMILES CC1(C)N(Cc2c(Nc3ncnc4ccsc34)[nH]nc12)C(=O)N[C@@H]1C[C@H]1c1ccccc1 |r| Show InChI InChI=1S/C23H23N7OS/c1-23(2)19-15(20(29-28-19)27-21-18-16(8-9-32-18)24-12-25-21)11-30(23)22(31)26-17-10-14(17)13-6-4-3-5-7-13/h3-9,12,14,17H,10-11H2,1-2H3,(H,26,31)(H2,24,25,27,28,29)/t14-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	18	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101513 (US8524699, 18 | US8530652, 40 | US8530652, 85) Show SMILES CC1(C)N(Cc2c(Nc3nc(nc4ccccc34)C#N)[nH]nc12)C(=O)N[C@@H]1C[C@H]1c1ccccc1 |r| Show InChI InChI=1S/C26H24N8O/c1-26(2)22-18(14-34(26)25(35)29-20-12-17(20)15-8-4-3-5-9-15)24(33-32-22)31-23-16-10-6-7-11-19(16)28-21(13-27)30-23/h3-11,17,20H,12,14H2,1-2H3,(H,29,35)(H2,28,30,31,32,33)/t17-,20+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	18	n/a	n/a	n/a	98	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101536 (CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...) Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C25H30N8OS/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2,3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H,28,34)(H2,26,27,29,30,31)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	US Patent	20	n/a	n/a	n/a	<3.90	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101504 (US8524699, 91 | US8524710, 82 | US8530652, 31) Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)c2ccsc2n1 |r| Show InChI InChI=1S/C24H25N7OS/c1-13-25-20(15-9-10-33-22(15)26-13)28-21-17-12-31(24(2,3)19(17)29-30-21)23(32)27-18-11-16(18)14-7-5-4-6-8-14/h4-10,16,18H,11-12H2,1-3H3,(H,27,32)(H2,25,26,28,29,30)/t16-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	20	n/a	n/a	n/a	103	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101507 (US8524710, 86 | US8530652, 34 | US8530652, 79) Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@@H]2C[C@H]2c2ccccc2)C3(C)C)cc(n1)N1CCOCC1 |r| Show InChI InChI=1S/C26H32N8O2/c1-16-27-21(14-22(28-16)33-9-11-36-12-10-33)30-24-19-15-34(26(2,3)23(19)31-32-24)25(35)29-20-13-18(20)17-7-5-4-6-8-17/h4-8,14,18,20H,9-13,15H2,1-3H3,(H,29,35)(H2,27,28,30,31,32)/t18-,20+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	21	n/a	n/a	n/a	778	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101534 (US8530494, 202 | US8530652, 112 | US8530652, 61) Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ncnc4sccc34)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C24H28N8OS/c1-24(2)19-17(21(30-29-19)28-20-16-10-11-34-22(16)26-14-25-20)12-32(24)23(33)27-18(13-31(3)4)15-8-6-5-7-9-15/h5-11,14,18H,12-13H2,1-4H3,(H,27,33)(H2,25,26,28,29,30)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	22	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101514 (US8524699, 22 | US8530652, 41 | US8530652, 86) Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)C3(C)C)c2sccc2n1 |r| Show InChI InChI=1S/C24H25N7OS/c1-13-25-17-9-10-33-19(17)22(26-13)28-21-16-12-31(24(2,3)20(16)29-30-21)23(32)27-18-11-15(18)14-7-5-4-6-8-14/h4-10,15,18H,11-12H2,1-3H3,(H,27,32)(H2,25,26,28,29,30)/t15-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	24	n/a	n/a	n/a	147	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101518 (US8524699, 46 | US8530652, 45 | US8530652, 90) Show SMILES CC1(C)N(Cc2c(Nc3nc(nc4ccsc34)C(F)(F)F)[nH]nc12)C(=O)N[C@@H]1C[C@H]1c1ccccc1 |r| Show InChI InChI=1S/C24H22F3N7OS/c1-23(2)18-14(11-34(23)22(35)29-16-10-13(16)12-6-4-3-5-7-12)19(33-32-18)30-20-17-15(8-9-36-17)28-21(31-20)24(25,26)27/h3-9,13,16H,10-11H2,1-2H3,(H,29,35)(H2,28,30,31,32,33)/t13-,16+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	25	n/a	n/a	n/a	32	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50389113 (CHEMBL2064558) Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(NC(=O)c3ccccc3)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C25H30N6O2/c1-25(2)21-19(22(29-28-21)27-23(32)18-13-9-6-10-14-18)15-31(25)24(33)26-20(16-30(3)4)17-11-7-5-8-12-17/h5-14,20H,15-16H2,1-4H3,(H,26,33)(H2,27,28,29,32)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PAK4				J Med Chem 55: 4728-39 (2012) Article DOI: 10.1021/jm300204j BindingDB Entry DOI: 10.7270/Q2BZ673W
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50389120 (CHEMBL2064565) Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)c3ccccn3)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C24H28N6O3/c1-24(2)20-17(21(28-27-20)26-22(31)18-12-8-9-13-25-18)14-30(24)23(32)33-19(15-29(3)4)16-10-6-5-7-11-16/h5-13,19H,14-15H2,1-4H3,(H2,26,27,28,31)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PAK4				J Med Chem 55: 4728-39 (2012) Article DOI: 10.1021/jm300204j BindingDB Entry DOI: 10.7270/Q2BZ673W
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101639 (US8530652, 84) Show SMILES Cc1nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@H]2c2ccccc2)C3(C)C)c2ccccc2n1 |r| Show InChI InChI=1S/C26H27N7O/c1-15-27-20-12-8-7-11-17(20)23(28-15)30-24-19-14-33(26(2,3)22(19)31-32-24)25(34)29-21-13-18(21)16-9-5-4-6-10-16/h4-12,18,21H,13-14H2,1-3H3,(H,29,34)(H2,27,28,30,31,32)/t18-,21?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	34	n/a	n/a	n/a	455	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101485 (US8524710, 62 | US8530652, 12 | US8530652, 56) Show SMILES CC1(C)N(Cc2c(Nc3nc(Cl)nc4ccccc34)[nH]nc12)C(=O)NC1CC1c1ccccc1 Show InChI InChI=1S/C25H24ClN7O/c1-25(2)20-17(13-33(25)24(34)28-19-12-16(19)14-8-4-3-5-9-14)22(32-31-20)29-21-15-10-6-7-11-18(15)27-23(26)30-21/h3-11,16,19H,12-13H2,1-2H3,(H,28,34)(H2,27,29,30,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	38	n/a	n/a	n/a	78	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101552 (US8530494, 214 | US8530652, 131 | US8530652, 79) Show SMILES COc1ncc(F)c(Nc2[nH]nc3c2CN(C(=O)O[C@H](CN(C)C)c2ccccc2)C3(C)C)n1 |r| Show InChI InChI=1S/C23H28FN7O3/c1-23(2)18-15(19(29-28-18)26-20-16(24)11-25-21(27-20)33-5)12-31(23)22(32)34-17(13-30(3)4)14-9-7-6-8-10-14/h6-11,17H,12-13H2,1-5H3,(H2,25,26,27,28,29)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	39	n/a	n/a	n/a	>3.90	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101533 (US8530494, 103 | US8530652, 111 | US8530652, 60) Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ccnc(n3)C#N)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C23H27N9O/c1-23(2)20-16(21(30-29-20)28-18-10-11-25-19(12-24)27-18)13-32(23)22(33)26-17(14-31(3)4)15-8-6-5-7-9-15/h5-11,17H,13-14H2,1-4H3,(H,26,33)(H2,25,27,28,29,30)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	40	n/a	n/a	n/a	<3.90	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101556 (US8530652, 1) Show SMILES CC1(C)N(Cc2c(Nc3ncnc4ccsc34)[nH]nc12)C(=O)N[C@H]1CC1c1ccccc1 |r| Show InChI InChI=1S/C23H23N7OS/c1-23(2)19-15(20(29-28-19)27-21-18-16(8-9-32-18)24-12-25-21)11-30(23)22(31)26-17-10-14(17)13-6-4-3-5-7-13/h3-9,12,14,17H,10-11H2,1-2H3,(H,26,31)(H2,24,25,27,28,29)/t14?,17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	41	n/a	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101506 (US8524710, 85 | US8530652, 33 | US8530652, 78) Show SMILES CC1(C)N(Cc2c(Nc3ccnc(n3)C#N)[nH]nc12)C(=O)N[C@@H]1C[C@H]1c1ccccc1 |r| Show InChI InChI=1S/C22H22N8O/c1-22(2)19-15(20(29-28-19)27-17-8-9-24-18(11-23)26-17)12-30(22)21(31)25-16-10-14(16)13-6-4-3-5-7-13/h3-9,14,16H,10,12H2,1-2H3,(H,25,31)(H2,24,26,27,28,29)/t14-,16+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	47	n/a	n/a	n/a	618	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101641 (US8530652, 86) Show SMILES CC1(C)N(Cc2c(Nc3nc(nc4ccccc34)C3CC3)[nH]nc12)C(=O)NC1C[C@H]1c1ccccc1 |r| Show InChI InChI=1S/C28H29N7O/c1-28(2)23-20(15-35(28)27(36)30-22-14-19(22)16-8-4-3-5-9-16)26(34-33-23)32-25-18-10-6-7-11-21(18)29-24(31-25)17-12-13-17/h3-11,17,19,22H,12-15H2,1-2H3,(H,30,36)(H2,29,31,32,33,34)/t19-,22?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101638 (US8530652, 83) Show SMILES CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ncnc4ccoc34)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C24H28N8O2/c1-24(2)20-16(21(30-29-20)28-22-19-17(10-11-34-19)25-14-26-22)12-32(24)23(33)27-18(13-31(3)4)15-8-6-5-7-9-15/h5-11,14,18H,12-13H2,1-4H3,(H,27,33)(H2,25,26,28,29,30)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	58	n/a	n/a	n/a	84	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50389109 (CHEMBL2064557) Show SMILES CN1CCN([C@@H](Cc2ccccc2)C1)C(=O)N1Cc2c(NC(=O)c3cccc(Oc4ccccc4)c3)[nH]nc2C1(C)C |r| Show InChI InChI=1S/C33H36N6O3/c1-33(2)29-28(22-39(33)32(41)38-18-17-37(3)21-25(38)19-23-11-6-4-7-12-23)30(36-35-29)34-31(40)24-13-10-16-27(20-24)42-26-14-8-5-9-15-26/h4-16,20,25H,17-19,21-22H2,1-3H3,(H2,34,35,36,40)/t25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	64	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PAK4				J Med Chem 55: 4728-39 (2012) Article DOI: 10.1021/jm300204j BindingDB Entry DOI: 10.7270/Q2BZ673W
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101526 (US8530494, 11 | US8530652, 53 | US8530652, 98) Show SMILES CC1(C)N(Cc2c(Nc3ncnc4ccoc34)n[nH]c12)C(=O)N[C@H]1C[C@@H]1c1ccccc1 |r| Show InChI InChI=1S/C23H23N7O2/c1-23(2)19-15(20(29-28-19)27-21-18-16(8-9-32-18)24-12-25-21)11-30(23)22(31)26-17-10-14(17)13-6-4-3-5-7-13/h3-9,12,14,17H,10-11H2,1-2H3,(H,26,31)(H2,24,25,27,28,29)/t14-,17+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	67	n/a	n/a	n/a	1.75E+3	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50389119 (CHEMBL2064564) Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)c3ccc(F)cc3F)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C25H27F2N5O3/c1-25(2)21-18(22(30-29-21)28-23(33)17-11-10-16(26)12-19(17)27)13-32(25)24(34)35-20(14-31(3)4)15-8-6-5-7-9-15/h5-12,20H,13-14H2,1-4H3,(H2,28,29,30,33)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	68	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PAK4				J Med Chem 55: 4728-39 (2012) Article DOI: 10.1021/jm300204j BindingDB Entry DOI: 10.7270/Q2BZ673W
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101489 (US8524710, 67 | US8530652, 16 | US8530652, 60) Show SMILES COc1nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)nc(n1)N1CCC[C@H]1CO |r| Show InChI InChI=1S/C26H33N9O3/c1-26(2)20-18(13-35(26)25(37)27-19-12-17(19)15-8-5-4-6-9-15)21(33-32-20)28-22-29-23(31-24(30-22)38-3)34-11-7-10-16(34)14-36/h4-6,8-9,16-17,19,36H,7,10-14H2,1-3H3,(H,27,37)(H2,28,29,30,31,32,33)/t16-,17+,19?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	76	n/a	n/a	n/a	1.27E+3	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101503 (US8524710, 81 | US8530652, 30 | US8530652, 74) Show SMILES CC1(C)N(Cc2c(Nc3ccnc(n3)C(F)(F)F)[nH]nc12)C(=O)NC1C[C@@H]1c1ccccc1 |r| Show InChI InChI=1S/C22H22F3N7O/c1-21(2)17-14(18(31-30-17)28-16-8-9-26-19(29-16)22(23,24)25)11-32(21)20(33)27-15-10-13(15)12-6-4-3-5-7-12/h3-9,13,15H,10-11H2,1-2H3,(H,27,33)(H2,26,28,29,30,31)/t13-,15?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	80	n/a	n/a	n/a	968	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101554 (US8530494, 210 | US8530652, 134 | US8530652, 81) Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(Nc3ncnc4c(C)csc34)[nH]nc2C1(C)C |r| Show InChI InChI=1S/C23H30N8OS/c1-13-11-33-18-17(13)24-12-25-21(18)26-20-16-10-31(23(3,4)19(16)27-28-20)22(32)30-9-15-6-5-7-29(15)8-14(30)2/h11-12,14-15H,5-10H2,1-4H3,(H2,24,25,26,27,28)/t14-,15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	84	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM101480 (US8524710, 57 | US8530652, 51 | US8530652, 7) Show SMILES CCCOc1nc(Cl)nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)n1 Show InChI InChI=1S/C23H27ClN8O2/c1-4-10-34-21-28-19(24)27-20(29-21)26-18-15-12-32(23(2,3)17(15)30-31-18)22(33)25-16-11-14(16)13-8-6-5-7-9-13/h5-9,14,16H,4,10-12H2,1-3H3,(H,25,33)(H2,26,27,28,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	87	n/a	n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM4827 (US8530652, 20) Show SMILES COc1nc(Nc2[nH]nc3c2CN(C(=O)NC2CC2c2ccccc2)C3(C)C)nc(n1)N1CCCC1C#N Show InChI InChI=1S/C26H30N10O2/c1-26(2)20-18(14-36(26)25(37)28-19-12-17(19)15-8-5-4-6-9-15)21(34-33-20)29-22-30-23(32-24(31-22)38-3)35-11-7-10-16(35)13-27/h4-6,8-9,16-17,19H,7,10-12,14H2,1-3H3,(H,28,37)(H2,29,30,31,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	90	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc.; Pfizer Inc. US Patent					Assay Description The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an a...				US Patent US8530652 (2013) BindingDB Entry DOI: 10.7270/Q2F18XC4
					More data for this Ligand-Target Pair

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