| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 4 |
|---|
| Ligand | BDBM101489 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Assay |
|---|
| Ki | 76±n/a nM |
|---|
| EC50 | 1267±0 nM |
|---|
| Citation |  Zhang, J; Guo, C; Bouzida, D; Dong, L; Li, H; Marakovits, JT; Yang, A; Hong, Y Pyrrolopyrazoles, potent kinase inhibitors US Patent US8530652 Publication Date 9/10/2013 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase PAK 4 |
|---|
| Name: | Serine/threonine-protein kinase PAK 4 |
|---|
| Synonyms: | KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 64098.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O96013 |
|---|
| Residue: | 591 |
|---|
| Sequence: | MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
|
|
|
|---|
| BDBM101489 |
|---|
| n/a |
|---|
| Name | BDBM101489 |
|---|
| Synonyms: | US8524710, 67 | US8530652, 16 | US8530652, 60 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H33N9O3 |
|---|
| Mol. Mass. | 519.5987 |
|---|
| SMILES | COc1nc(Nc2[nH]nc3c2CN(C(=O)NC2C[C@@H]2c2ccccc2)C3(C)C)nc(n1)N1CCC[C@H]1CO |r| |
|---|
| Structure | 
|
|---|
Search and Browse
