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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM102427 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 32±0.0 nM | ||
| Citation |  Crespin, O; Nicolai, E; Venier, O Tetrahydroquinoxaline urea derivatives as modulators of 11-B-hydroxysteroid dehydrogenase type I US Patent US8536173 Publication Date 9/17/2013 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
| ||
| BDBM102427 | |||
| n/a | |||
| Name | BDBM102427 | ||
| Synonyms: | US8536173, 2 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C34H49N7O3S | ||
| Mol. Mass. | 635.863 | ||
| SMILES | CC(C)(C)N1CCN(CC1)c1ccc(nc1)N1CCN(C(=O)N[C@H]2C3CC4CC2C[C@@](CNS(C)(=O)=O)(C4)C3)c2ccccc12 |r,wU:23.24,wD:30.33,THB:25:26:29:23.38.24,37:26:23:29.30.38,(-12.42,-.67,;-10.88,-.67,;-10.88,.87,;-10.88,-2.21,;-9.34,-.67,;-8.57,-2,;-7.03,-2,;-6.26,-.67,;-7.03,.67,;-8.57,.67,;-4.72,-.67,;-3.95,.67,;-2.41,.67,;-1.64,-.67,;-2.41,-2,;-3.95,-2,;-.1,-.67,;.67,-2,;2.21,-2,;2.98,-.67,;4.52,-.67,;5.29,.67,;5.29,-2,;6.83,-2,;7.6,-.67,;7.6,-1.95,;8.46,-1.95,;8.69,-2.8,;7.6,-3.33,;9.14,-3.33,;9.91,-2,;11.45,-2,;12.22,-.67,;13.76,-.67,;15.3,-.67,;13.76,-2.21,;13.76,.87,;8.85,-1.28,;9.14,-.67,;2.21,.67,;2.98,2,;2.21,3.33,;.67,3.33,;-.1,2,;.67,.67,)| | ||
| Structure | 
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