Reaction Details | |||
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Target | Fibroblast growth factor receptor 3 | ||
Ligand | BDBM102531 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
IC50 | 20±0.0 nM | ||
Citation | Furet, P; Graus Porta, D; Guagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent US8536175 Publication Date 9/17/2013 | ||
More Info.: | Get all data from this article, Assay Method | ||
Fibroblast growth factor receptor 3 | |||
Name: | Fibroblast growth factor receptor 3 | ||
Synonyms: | CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4 | ||
Type: | Protein | ||
Mol. Mass.: | 87699.57 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P22607 | ||
Residue: | 806 | ||
Sequence: |
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BDBM102531 | |||
n/a | |||
Name | BDBM102531 | ||
Synonyms: | US8536175, 106 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H30Cl2N6O4 | ||
Mol. Mass. | 597.492 | ||
SMILES | COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(CCO)CC3)cn2)c2nccnc12 |(11.55,2.62,;10.01,2.62,;9.24,1.28,;10.01,-.05,;9.24,-1.38,;10.01,-2.72,;11.55,-2.72,;7.7,-1.38,;6.93,-2.72,;6.93,-.05,;7.7,1.28,;6.93,2.61,;5.39,-.05,;4.62,1.28,;3.08,1.28,;2.31,-.05,;.77,-.05,;0,1.28,;0,-1.38,;-1.54,-1.38,;-2.31,-.05,;-3.85,-.05,;-4.62,-1.38,;-6.16,-1.38,;-6.93,-.05,;-6.16,1.28,;-6.93,2.62,;-8.47,2.62,;-9.24,3.95,;-10.78,3.95,;-11.55,2.62,;-9.24,1.28,;-8.47,-.05,;-3.85,-2.72,;-2.31,-2.72,;3.08,-1.38,;2.31,-2.72,;3.08,-4.05,;4.62,-4.05,;5.39,-2.72,;4.62,-1.38,)| | ||
Structure |