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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 8 | ||
| Ligand | BDBM102558 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In Vitro Inhibition Assay | ||
| pH | 7.5±0 | ||
| IC50 | 19.1±n/a nM | ||
| Citation |  Gong, L; Han, X; Makra, F; Palmer, WS; Raptova, L Inhibitors of JNK US Patent US8536172 Publication Date 9/17/2013 | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Mitogen-activated protein kinase 8 | |||
| Name: | Mitogen-activated protein kinase 8 | ||
| Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 48297.57 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). | ||
| Residue: | 427 | ||
| Sequence: |
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| BDBM102558 | |||
| n/a | |||
| Name | BDBM102558 | ||
| Synonyms: | US8536172, I-7 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H32N8O3S | ||
| Mol. Mass. | 512.628 | ||
| SMILES | CS(=O)(=O)N[C@H]1CC[C@@H](CC1)Nc1nccc(n1)-n1ccc2c(cccc12)N1CCN(CC1)C(N)=O |r,wU:8.11,wD:5.4,(-8.41,-3.47,;-7.08,-4.24,;-7.08,-5.78,;-5.75,-5.01,;-5.75,-3.47,;-5.75,-1.93,;-4.41,-1.16,;-4.41,.38,;-5.75,1.15,;-7.08,.38,;-7.08,-1.16,;-5.75,2.69,;-4.41,3.46,;-4.41,5,;-3.08,5.78,;-1.74,5,;-1.74,3.46,;-3.08,2.69,;-.41,2.69,;1.05,3.17,;1.96,1.92,;1.05,.68,;1.37,-.83,;.23,-1.86,;-1.24,-1.38,;-1.56,.12,;-.41,1.15,;2.86,-1.23,;3.26,-2.71,;4.75,-3.11,;5.84,-2.02,;5.44,-.54,;3.95,-.14,;7.32,-2.42,;7.72,-3.91,;8.41,-1.33,)| | ||
| Structure | 
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