Reaction Details | |||
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Target | Mitogen-activated protein kinase 8 | ||
Ligand | BDBM102563 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | In Vitro Inhibition Assay | ||
pH | 7.5±0 | ||
IC50 | 3.1±n/a nM | ||
Citation | Gong, L; Han, X; Makra, F; Palmer, WS; Raptova, L Inhibitors of JNK US Patent US8536172 Publication Date 9/17/2013 | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Mitogen-activated protein kinase 8 | |||
Name: | Mitogen-activated protein kinase 8 | ||
Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) | ||
Type: | Enzyme | ||
Mol. Mass.: | 48297.57 | ||
Organism: | Homo sapiens (Human) | ||
Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). | ||
Residue: | 427 | ||
Sequence: |
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BDBM102563 | |||
n/a | |||
Name | BDBM102563 | ||
Synonyms: | US8536172, I-12 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H31N5O3S | ||
Mol. Mass. | 469.6 | ||
SMILES | CS(=O)(=O)C1CCN(CC1)c1cccc2n(ccc12)-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:25.27,wD:28.31,(5.57,-4.44,;6.66,-3.35,;7.75,-2.27,;7.06,-4.84,;5.17,-2.96,;4.08,-4.04,;2.59,-3.65,;2.19,-2.16,;3.28,-1.07,;4.77,-1.47,;.71,-1.76,;-.44,-2.79,;-1.9,-2.31,;-2.22,-.81,;-1.08,.22,;-1.08,1.76,;.39,2.24,;1.29,.99,;.39,-.25,;-2.41,2.53,;-2.41,4.07,;-3.75,4.84,;-5.08,4.07,;-5.08,2.53,;-6.41,1.76,;-6.41,.22,;-5.08,-.55,;-5.08,-2.09,;-6.41,-2.86,;-6.41,-4.4,;-7.75,-2.09,;-7.75,-.55,;-3.75,1.76,)| | ||
Structure |