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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 8 | ||
| Ligand | BDBM102601 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In Vitro Inhibition Assay | ||
| pH | 7.5±0 | ||
| IC50 | 15.6±n/a nM | ||
| Citation |  Gong, L; Han, X; Makra, F; Palmer, WS; Raptova, L Inhibitors of JNK US Patent US8536172 Publication Date 9/17/2013 | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Mitogen-activated protein kinase 8 | |||
| Name: | Mitogen-activated protein kinase 8 | ||
| Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 48297.57 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). | ||
| Residue: | 427 | ||
| Sequence: |
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| BDBM102601 | |||
| n/a | |||
| Name | BDBM102601 | ||
| Synonyms: | US8536172, I-50 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H45N7O3S | ||
| Mol. Mass. | 619.821 | ||
| SMILES | CS(=O)(=O)C1CCN(CC1)c1cccc2n(ccc12)-c1ccnc(N[C@H]2CC[C@@H](CC2)C(=O)N2CCN3CCCCC3C2)n1 |r,wU:25.27,wD:28.34,(8.29,10.96,;7.2,9.87,;6.11,10.96,;8.29,8.78,;6.11,8.78,;6.51,7.29,;5.42,6.2,;3.93,6.6,;3.53,8.09,;4.62,9.18,;2.84,5.51,;3.47,4.1,;2.56,2.86,;1.03,3.02,;.4,4.43,;-1.06,4.9,;-1.06,6.44,;.4,6.92,;1.31,5.67,;-2.15,3.81,;-3.64,4.21,;-4.73,3.12,;-4.33,1.64,;-2.84,1.24,;-2.44,-.25,;-3.53,-1.34,;-3.13,-2.83,;-4.22,-3.92,;-5.71,-3.52,;-6.11,-2.03,;-5.02,-.94,;-6.8,-4.61,;-8.29,-4.21,;-6.4,-6.09,;-7.49,-7.18,;-7.09,-8.67,;-5.6,-9.07,;-5.2,-10.56,;-3.72,-10.96,;-2.63,-9.87,;-3.03,-8.38,;-4.51,-7.98,;-4.91,-6.49,;-1.75,2.33,)| | ||
| Structure | 
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