| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase receptor R3 |
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| Ligand | BDBM50262079 |
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| Substrate/Competitor | n/a |
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| IC50 | 1.48±0.0 nM |
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| Citation |  Mohedas, AH; Xing, X; Armstrong, KA; Bullock, AN; Cuny, GD; Yu, PB Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor. ACS Chem Biol8:1291-302 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Serine/threonine-protein kinase receptor R3 |
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| Name: | Serine/threonine-protein kinase receptor R3 |
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| Synonyms: | ACVL1_MOUSE | AI115505 | AI427544 | ALK1 | Acvrl1 | Acvrlk1 | Alk-1 |
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| Type: | Protein |
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| Mol. Mass.: | 56529.91 |
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| Organism: | Mus musculus |
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| Description: | n/a |
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| Residue: | 502 |
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| Sequence: | MTLGSFRRGLLMLSVAFGLTRGDLAKPSKLVNCTCESPHCKRPFCQGSWCTVVLVREQGR
HPQVYRGCGSLNQELCLGRPTEFLNHHCCYRSFCNHNVSLMLEATQTPSEEPEVDAHLPL
ILGPVLALPVLVALGALGLWRVRRRQEKQRDLHSDLGESSLILKASEQADSMLGDFLDSD
CTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFR
ETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALR
LAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDY
LDIGNNPRVGTKRYMAPEVLDEHIRTDCFESYKWTDIWAFGLVLWEIARRTIINGIVEDY
RPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLT
ALRIKKTLQKLSHNPEKPKVIH
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| BDBM50262079 |
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| n/a |
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| Name | BDBM50262079 |
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| Synonyms: | 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | CHEMBL513147 | LDN-193189 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N6 |
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| Mol. Mass. | 406.4824 |
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| SMILES | C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 |
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| Structure | 
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