| Reaction Details |
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 | Report a problem with these data |
| Target | Activin receptor type-1B |
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| Ligand | BDBM36354 |
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| Substrate/Competitor | n/a |
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| IC50 | 11023±0.0 nM |
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| Citation |  Mohedas, AH; Xing, X; Armstrong, KA; Bullock, AN; Cuny, GD; Yu, PB Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor. ACS Chem Biol8:1291-302 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Activin receptor type-1B |
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| Name: | Activin receptor type-1B |
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| Synonyms: | 6820432J04 | ACV1B_MOUSE | ActR-IB | ActRIB | Acvr1b | Acvrlk4 | Alk4 | SKR2 |
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| Type: | n/a |
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| Mol. Mass.: | 56705.93 |
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| Organism: | Mus musculus |
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| Description: | n/a |
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| Residue: | 505 |
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| Sequence: | MAESAGASSFFPLVVLLLAGSGGSGPRGIQALLCACTSCLQTNYTCETDGACMVSIFNLD
GVEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYIDFCNKIDLRVPSGHLKEPAHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEDYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
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| BDBM36354 |
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| n/a |
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| Name | BDBM36354 |
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| Synonyms: | 4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin- 3-yl)quinoline | DMH1 | US9040694, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20N4O |
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| Mol. Mass. | 380.4418 |
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| SMILES | CC(C)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 |
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| Structure | 
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