Reaction Details |
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Target | Tumor necrosis factor |
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Ligand | BDBM102843 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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Ki | 0.093±0.0 nM |
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IC50 | 74±0.0 nM |
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Citation | Kozlowski, JA; Yu, W; Wong, MK; Kim, SH; Tong, L; Lavey, BJ; Shankar, BB; Yang, D; Feltz, R; Kosinski, AM; Zhou, G; Rizvi, RK; Dai, C; Fire, L; Girijavallabhan, V; Li, D; Popovici-Muller, J; Richard, JE; Rosner, KE; Siddiqui, MA; Yang, L Compounds for the treatment of inflammatory disorders US Patent US8541572 Publication Date 9/24/2013 |
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More Info.: | Get all data from this article, Assay Method |
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Tumor necrosis factor |
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Name: | Tumor necrosis factor |
Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
Type: | Enzyme |
Mol. Mass.: | 25645.11 |
Organism: | Homo sapiens (Human) |
Description: | P01375 |
Residue: | 233 |
Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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BDBM102843 |
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n/a |
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Name | BDBM102843 |
Synonyms: | US8541572, 925 |
Type | Small organic molecule |
Emp. Form. | C30H34N6O5 |
Mol. Mass. | 558.6282 |
SMILES | CCCCN1CCN(CC1)C(=NO)c1ccc(cc1)C#C[C@]1(CN2Cc3ccc(OC)cc3C2=O)NC(=O)NC1=O |r,w:11.12| |
Structure |
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