Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTumor necrosis factor
LigandBDBM102846
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 0.15±0.0 nM
IC50 278±0.0 nM
Citation Kozlowski, JAYu, WWong, MKKim, SHTong, LLavey, BJShankar, BBYang, DFeltz, RKosinski, AMZhou, GRizvi, RKDai, CFire, LGirijavallabhan, VLi, DPopovici-Muller, JRichard, JERosner, KESiddiqui, MAYang, L Compounds for the treatment of inflammatory disorders US Patent US8541572 Publication Date 9/24/2013
More Info.:Get all data from this article,  Assay Method
 
Tumor necrosis factor
Name:Tumor necrosis factor
Synonyms:Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:Enzyme
Mol. Mass.:25645.11
Organism:Homo sapiens (Human)
Description:P01375
Residue:233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM102846
n/a
NameBDBM102846
Synonyms:US8541572, 928
TypeSmall organic molecule
Emp. Form.C32H30N6O5
Mol. Mass.578.6178
SMILESCOc1ccc2CN(C[C@]3(NC(=O)NC3=O)C#Cc3ccc(cc3)C(N=O)N3CCN(CC3)c3ccccc3)C(=O)c2c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: