| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin S |
|---|
| Ligand | BDBM103365 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Inhibition Assay |
|---|
| Ki | 32±0.0 nM |
|---|
| Citation |  Quibell, M; Watts, JP; Flinn, NS Furo[3, 2-B] pyrrol-3-ones as cathespin S inhibitors US Patent US8552202 Publication Date 10/8/2013 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin S |
|---|
| Name: | Cathepsin S |
|---|
| Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 37507.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25774 |
|---|
| Residue: | 331 |
|---|
| Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
|
|
|
|---|
| BDBM103365 |
|---|
| n/a |
|---|
| Name | BDBM103365 |
|---|
| Synonyms: | US8552202, Compound 14 |
|---|
| Type | Small organic molecules |
|---|
| Emp. Form. | C24H27ClN4O4 |
|---|
| Mol. Mass. | 470.949 |
|---|
| SMILES | Cl[C@@H]1CN([C@H]2[C@@H]1OCC2=O)C(=O)[C@@H](NC(=O)c1cccc(c1)-n1ccnc1)C1CCCCC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
