| Reaction Details |
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 | Report a problem with these data |
| Target | Amyloid-beta precursor protein |
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| Ligand | BDBM103948 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Pharmacological Assay |
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| IC50 | 1±0.0 nM |
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| Citation |  Asberom, T; Bara, TA; Bennett, CE; Burnett, DA; Caplen, MA; Clader, JW; Cole, DJ; Domalski, MS; Josien, HB; Knutson, CE; Li, H; McBriar, MD; Pissarnitski, DA; Qiang, L; Rajagopalan, M; Sasikumar, TK; Su, J; Tang, H; Wu, W; Xu, R; Zhao, Z Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors US Patent US8569521 Publication Date 10/29/2013 |
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| More Info.: | Get all data from this article, Assay Method |
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| Amyloid-beta precursor protein |
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| Name: | Amyloid-beta precursor protein |
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| Synonyms: | A4 | A4_HUMAN | ABPP | AD1 | AICD-50 | AICD-57 | AICD-59 | AID(50) | AID(57) | AID(59) | APP | APPI | Alzheimer disease amyloid protein | Amyloid beta A4 protein | Amyloid beta Protein | Amyloid beta protein (sAPPbeta) | Amyloid beta protein Abeta(1-42) | Amyloid intracellular domain 50 | Amyloid intracellular domain 57 | Amyloid intracellular domain 59 | Amyloid protein (Abeta42b) | Amyloid β-protein (Aβ42) | Beta amyloid A4 protein | Beta-APP40 | Beta-APP42 | Beta-amyloid protein 40 | Beta-amyloid protein 42 | C31 | C83 | C99 | CVAP | Cerebral vascular amyloid peptide | Gamma Secretase | Gamma-CTF(50) | Gamma-CTF(57) | Gamma-CTF(59) | Gamma-secretase | Gamma-secretase C-terminal fragment 50 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | P3(40) | P3(42) | PN-II | PreA4 | Protease nexin-II | S-APP-alpha | S-APP-beta | Soluble APP-alpha | Soluble APP-beta | beta-Amyloid Precursor Protein (APP) |
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| Type: | Single-pass type I membrane protein |
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| Mol. Mass.: | 86890.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05067 |
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| Residue: | 770 |
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| Sequence: | MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
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| BDBM103948 |
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| n/a |
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| Name | BDBM103948 |
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| Synonyms: | US8569521, 144 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24ClF2NO5S2 |
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| Mol. Mass. | 520.009 |
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| SMILES | CCS(=O)(=O)NC[C@@H]1CCC[C@@]2([C@H]1COc1c(F)ccc(F)c21)S(=O)(=O)c1ccc(Cl)cc1 |r| |
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| Structure | 
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