| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase beta |
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| Ligand | BDBM104081 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DNA Pol β PEX Assay |
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| pH | 7.9±n/a |
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| IC50 | 2.81e+4±n/a nM |
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| Comments | extracted |
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| Citation |  Strittmatter, T; Brockmann, A; Pott, M; Hantusch, A; Brunner, T; Marx, A Expanding the Scope of Human DNA Polymerase ¿ and ß Inhibitors. ACS Chem Biol9:282-90 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase beta |
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| Name: | DNA polymerase beta |
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| Synonyms: | DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB |
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| Type: | Protein |
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| Mol. Mass.: | 38188.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 335 |
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| Sequence: | MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
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| BDBM104081 |
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| n/a |
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| Name | BDBM104081 |
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| Synonyms: | (Z)-2-Thioxo-5-(4-(p-tolylthio)-3- (trifluoromethyl)benzylidene)thiazolidin-4-one 15 | DNA polymerase inhibitor 15 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H12F3NOS3 |
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| Mol. Mass. | 411.484 |
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| SMILES | Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2C(F)(F)F)cc1 |w:10.9,c:14| |
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| Structure | 
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