| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM104827 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 85.0±0.0 nM |
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| Citation |  Von Nussbaum, F; Karthaus, D; Anlauf, S; Delbeck, M; Li, VM; Meibom, D; Lustig, K Triazolo and tetrazolo pyrimidine derivatives as HNE inhibitors for treating COPD US Patent US8569314 Publication Date 10/29/2013 |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM104827 |
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| n/a |
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| Name | BDBM104827 |
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| Synonyms: | US8569314, 67 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19F3N6 |
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| Mol. Mass. | 448.4431 |
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| SMILES | CC(C)c1nc2N(C(C)=C([N+]#[C-])C(c3ccc(cc3)C#N)n2n1)c1cccc(c1)C(F)(F)F |t:8| |
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| Structure | 
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