Reaction Details |
| Report a problem with these data |
Target | Neutrophil elastase |
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Ligand | BDBM104828 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | 3.0±0.0 nM |
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Citation | Von Nussbaum, F; Karthaus, D; Anlauf, S; Delbeck, M; Li, VM; Meibom, D; Lustig, K Triazolo and tetrazolo pyrimidine derivatives as HNE inhibitors for treating COPD US Patent US8569314 Publication Date 10/29/2013 |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM104828 |
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n/a |
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Name | BDBM104828 |
Synonyms: | US8569314, 78 |
Type | Small organic molecule |
Emp. Form. | C26H19F3N6O2 |
Mol. Mass. | 504.4633 |
SMILES | CCOC(=O)C1=C(C)N(c2nc3cncnc3n2C1c1ccc(cc1)C#N)c1cccc(c1)C(F)(F)F |c:5| |
Structure |
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