| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15B |
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| Ligand | BDBM106788 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IC50 Assay |
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| pH | 7.5±0 |
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| Temperature | 296.15±0 K |
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| IC50 | 3.3e+4±n/a nM |
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| Citation |  Mascayano, C; Espinosa, V; Sepúlveda-Boza, S; Sepúlveda-Boza, EK; Perry, S In vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases. Chem Biol Drug Des82:317-25 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX15B |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15B |
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| Synonyms: | 15-LOX-2 | 15-Lipo-oxygenase type 2 (15-LOX-2) | 15-Lipoxygenase-2 (15-LOX-2) | 15-lipoxygenase 2 | ALOX15B | Arachidonate 15-lipoxygenase type II | Arachidonate 15-lipoxygenase, type II | Arachidonate 15-lipoxygenase-2 | Epithelial 15-lipoxygenase-2 | LX15B_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 75850.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 676 |
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| Sequence: | MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPED
VGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQE
GTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAK
NANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFAS
QFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQT
NVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWV
RNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELL
IVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQI
WGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQ
YVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNAT
CDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVL
PYTYLDPPLIENSVSI
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| BDBM106788 |
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| n/a |
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| Name | BDBM106788 |
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| Synonyms: | 3‐(3‐methylphenyl)‐3,4‐dihydro‐2H‐1‐benzopyran‐7,8‐ diol | 7,8-Dihydroxy-3′-methylisoflavan (5c) | HIR-309 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16O3 |
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| Mol. Mass. | 256.2964 |
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| SMILES | Cc1cccc(c1)C1COc2c(C1)ccc(O)c2O |
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| Structure | 
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