| Reaction Details |
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 | Report a problem with these data |
| Target | MAP/microtubule affinity-regulating kinase 3 |
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| Ligand | BDBM107111 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Homogenous Time-Resolved Fluorescence (HTRF) Assay |
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| IC50 | 140±0.0 nM |
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| Citation |  Altman, MD; Bilodeau, MT; Lim, J; Northrup, A; Stanton, MG; Taoka, BM Imidazo[1,2-a]pyridines and imidazo[1,2-b]pyridazines as mark inhibitors US Patent US8592425 Publication Date 11/26/2013 |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP/microtubule affinity-regulating kinase 3 |
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| Name: | MAP/microtubule affinity-regulating kinase 3 |
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| Synonyms: | 2.7.11.1 | C-TAK1 | CTAK1 | Cdc25C-associated protein kinase 1 | ELKL motif kinase 2 | EMK-2 | EMK2 | MAP/microtubule affinity-regulating kinase 3 | MAP/microtubule affinity-regulating kinase 3 (MARK 3) | MARK3 | MARK3_HUMAN | Par-1a | Protein kinase STK10 | Ser/Thr protein kinase PAR-1 | Serine/threonine-protein kinase c-TAK1 | Serine/threonine-protein kinase p78 |
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| Type: | Protein |
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| Mol. Mass.: | 84525.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27448 |
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| Residue: | 753 |
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| Sequence: | MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK
TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE
VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ
IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT
YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSD
HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK
ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS
THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG
STNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRF
TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL
PRLSLNGVRFKRISGTSIAFKNIASKIANELKL
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| BDBM107111 |
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| n/a |
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| Name | BDBM107111 |
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| Synonyms: | US8592425, 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23F2N5OS |
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| Mol. Mass. | 419.491 |
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| SMILES | CCc1sc(cc1-c1cnc2cc(C)cnn12)C(=O)NC1[C@H](N)CCCC1(F)F |r| |
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| Structure | 
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