Reaction Details | |||
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Target | Metabotropic glutamate receptor 5 | ||
Ligand | BDBM107260 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Cell Based Assay | ||
IC50 | >30000±0 nM | ||
Citation | Conn, PJ; Lindsley, CW; Emmitte, KA; Weaver, CD; Rodriguez, AL; Felts, AS; Jones, CK; Bates, BS Substituted heteroarylamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same US Patent US8598345 Publication Date 12/3/2013 | ||
More Info.: | Get all data from this article, Assay Method | ||
Metabotropic glutamate receptor 5 | |||
Name: | Metabotropic glutamate receptor 5 | ||
Synonyms: | GRM5_RAT | Gprc1e | Grm5 | Metabotropic glutamate receptor | Mglur5 | metabotropic glutamate 5 | metabotropic glutamate 5/1-C | metabotropic glutamate 5/1-F | metabotropic glutamate 5a | ||
Type: | Enzyme | ||
Mol. Mass.: | 131900.14 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | P31424 | ||
Residue: | 1203 | ||
Sequence: |
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BDBM107260 | |||
n/a | |||
Name | BDBM107260 | ||
Synonyms: | US8598345, Table 1-46 | ||
Type | Small organic molecule | ||
Emp. Form. | C17H19N3O3 | ||
Mol. Mass. | 313.3511 | ||
SMILES | O[C@H]1CC[C@@H](CC1)NC(=O)c1cc(Oc2cccnc2)ccn1 |r,wU:4.7,wD:1.0,(5.33,-5,;4,-4.23,;4,-2.69,;2.67,-1.93,;1.33,-2.69,;1.33,-4.23,;2.67,-5,;,-1.93,;-1.33,-2.69,;-1.33,-4.23,;-2.67,-1.93,;-2.67,-.38,;-4,.38,;-4,1.93,;-2.67,2.69,;-2.67,4.23,;-1.33,5,;,4.23,;,2.69,;-1.33,1.93,;-5.33,-.38,;-5.33,-1.93,;-4,-2.69,)| | ||
Structure |