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Target1-Deoxy-D-xylulose-5-phosphate synthase (DXP synthase))
LigandBDBM50065935
Substrate/Competitorn/a
Meas. Tech.DXP Synthase Inhibition Assay
pH8±n/a
Temperature310.15±n/a K
IC50 2.08e+5± 2.0e+4 nM
Commentsextracted
Citation Morris FVierling RBoucher LBosch JFreel Meyers CL DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design. Chembiochem 14:1309-15 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
1-Deoxy-D-xylulose-5-phosphate synthase (DXP synthase))
Name:1-Deoxy-D-xylulose-5-phosphate synthase (DXP synthase))
Synonyms:n/a
Type:Protein
Mol. Mass.:67617.17
Organism:Escherichia coli K-12 (Enterobacteria)
Description:n/a
Residue:620
Sequence:
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
GHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILND
NEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
VPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFP
DRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDR
AGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
AVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDE
ALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEM
RAELGLDAAGMEAKIKAWLA
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  Blast E-value cutoff:
BDBM50065935
n/a
NameBDBM50065935
Synonyms:CHEMBL98797 | NOB | Nitrosobenzene (Substrate 1) | nitrosobenzene
TypeSmall organic molecule
Emp. Form.C6H5NO
Mol. Mass.107.11
SMILESO=Nc1ccccc1
Structure
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