| Reaction Details |
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 | Report a problem with these data |
| Target | 3-phosphoinositide-dependent protein kinase 1 [51-359] |
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| Ligand | BDBM282377 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PDK1 kinase assay |
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| IC50 | <100±n/a nM |
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| Citation |  Arndt, J; Chan, T; Guckian, K; Kumaravel, G; Lee, W; Lin, EY; Scott, D; Sun, L; Thomas, J; van Vloten, K; Wang, D; Zhang, L; Erlanson, D Heterocyclic compounds useful as PDK1 inhibitors US Patent US10030016 Publication Date 7/24/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-phosphoinositide-dependent protein kinase 1 [51-359] |
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| Name: | 3-phosphoinositide-dependent protein kinase 1 [51-359] |
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| Synonyms: | 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (aa 51-359) | PDK1 | PDK1 (aa 51-359) | PDPK1 | PDPK1_HUMAN | hPDK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 35302.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15530[51-359] |
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| Residue: | 309 |
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| Sequence: | MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAI
KILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKY
IRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVL
SPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLI
FQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL
HQQTPPKLT
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| BDBM282377 |
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| n/a |
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| Name | BDBM282377 |
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| Synonyms: | (S)-2-(3-(2-aminoquinazolin- 6-yl)prop-2-ynylamino)-5- cyano-N-(1-(4-fluorophenyl) ethyl)nicotinamide | US10030016, Example 257 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H20FN7O |
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| Mol. Mass. | 465.4817 |
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| SMILES | C[C@H](NC(=O)c1cc(cnc1NCC#Cc1ccc2nc(N)ncc2c1)C#N)c1ccc(F)cc1 |r| |
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| Structure | 
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