| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Ligand | BDBM111891 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Scintillation Proximity Assay |
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| pH | 7.5±0 |
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| Temperature | 273.15±0 K |
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| IC50 | 12±0 nM |
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| Citation |  Giovannini, R; Dorner-Ciossek, C; Eickmeier, C; Fiegen, D; Fox, T; Fuchs, K; Heine, N; Rosenbrock, H; Schaenzle, G Compounds for the treatment of CNS disorders US Patent US8623901 Publication Date 1/7/2014 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A) |
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| Type: | Protein |
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| Mol. Mass.: | 68488.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O76083 |
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| Residue: | 593 |
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| Sequence: | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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| BDBM111891 |
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| n/a |
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| Name | BDBM111891 |
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| Synonyms: | US8623901, 219 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21N5O2 |
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| Mol. Mass. | 387.4344 |
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| SMILES | O=c1[nH]c(Cc2ccccc2-c2cccnc2)nc2n(ncc12)C1CCOCC1 |
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| Structure | 
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