Ki Summary

Reaction Details

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Target

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T]

Ligand

BDBM114234

Substrate/Competitor

n/a

Meas. Tech.

Counterscreen for inhibitors of phospholipase C isozymes (PLC-B3): Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1)

IC50

122440±n/a nM

Citation

PubChem, PC Counterscreen for inhibitors of phospholipase C isozymes (PLC-B3): Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1) PubChem Bioassay(2014)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T]

Name:

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T]

Synonyms:

PLC1 | PLCG1 | PLCG1_HUMAN | Phospholipase C, gamma 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

115282.60

Organism:

Homo sapiens (Human)

Description:

gi_223459640

Residue:

999

Sequence:

MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKK

BDBM114234

n/a

Name

BDBM114234

Synonyms:

4-tert-butyl-N-phenyl-1-cyclohexanecarboxamide | 4-tert-butyl-N-phenyl-cyclohexane-1-carboxamide | 4-tert-butyl-N-phenyl-cyclohexanecarboxamide | 4-tert-butyl-N-phenylcyclohexane-1-carboxamide | MLS000536601 | SMR000151524 | cid_2118495

Type

Small organic molecule

Emp. Form.

C17H25NO

Mol. Mass.

259.3865

SMILES

CC(C)(C)C1CCC(CC1)C(=O)Nc1ccccc1 |(5.75,6.55,;5.75,5.01,;7.29,5.01,;4.21,5.01,;5.75,3.47,;4.41,2.7,;4.41,1.16,;5.75,.39,;7.08,1.16,;7.08,2.7,;5.75,-1.16,;7.08,-1.93,;4.41,-1.93,;4.41,-3.47,;3.08,-4.24,;3.08,-5.78,;4.41,-6.55,;5.75,-5.78,;5.75,-4.24,)|

Structure