| Reaction Details |
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 | Report a problem with these data |
| Target | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T] |
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| Ligand | BDBM114241 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Counterscreen for inhibitors of phospholipase C isozymes (PLC-B3): Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1) |
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| IC50 | 122473±n/a nM |
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| Citation |  PubChem, PC Counterscreen for inhibitors of phospholipase C isozymes (PLC-B3): Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1) PubChem Bioassay(2014)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T] |
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| Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T] |
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| Synonyms: | PLC1 | PLCG1 | PLCG1_HUMAN | Phospholipase C, gamma 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 115282.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_223459640 |
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| Residue: | 999 |
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| Sequence: | MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKK
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| BDBM114241 |
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| n/a |
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| Name | BDBM114241 |
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| Synonyms: | 1-(1-adamantyl)-4-nitro-N-(p-tolyl)pyrazole-3-carboxamide | 1-(1-adamantyl)-N-(4-methylphenyl)-4-nitro-1H-pyrazole-3-carboxamide | 1-(1-adamantyl)-N-(4-methylphenyl)-4-nitro-3-pyrazolecarboxamide | 1-(1-adamantyl)-N-(4-methylphenyl)-4-nitro-pyrazole-3-carboxamide | 1-(1-adamantyl)-N-(4-methylphenyl)-4-nitropyrazole-3-carboxamide | MLS000570890 | SMR000193312 | cid_2870878 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N4O3 |
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| Mol. Mass. | 380.4403 |
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| SMILES | [H]C12CC3([H])CC([H])(C1)CC(C2)(C3)n1cc(c(n1)C(=O)Nc1ccc(C)cc1)[N+]([O-])=O |TLB:8:1:12:6.9.5,8:6:12:1.11.2,THB:2:1:9:3.12.5,2:3:9:1.11.8| |
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| Structure | 
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