| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Major prion protein |
|---|
| Ligand | BDBM66187 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) |
|---|
| IC50 | 4555±n/a nM |
|---|
| Citation |  PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay(2014)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Major prion protein |
|---|
| Name: | Major prion protein |
|---|
| Synonyms: | ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 27671.97 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_158887 |
|---|
| Residue: | 253 |
|---|
| Sequence: | MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG
|
|
|
|---|
| BDBM66187 |
|---|
| n/a |
|---|
| Name | BDBM66187 |
|---|
| Synonyms: | 5,5-Dimethyl-2-thioxo-2,3,5,6-tetrahydro-1H-benzo[h]quinazolin-4-one | 5,5-dimethyl-2-sulfanylidene-1,6-dihydrobenzo[h]quinazolin-4-one | 5,5-dimethyl-2-thioxo-1,6-dihydrobenzo[h]quinazolin-4-one | MLS001211957 | SMR000505168 | cid_713572 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H14N2OS |
|---|
| Mol. Mass. | 258.339 |
|---|
| SMILES | CC1(C)Cc2ccccc2-c2[nH]c(=S)[nH]c(=O)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
