| Reaction Details |
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 | Report a problem with these data |
| Target | Aldehyde dehydrogenase, mitochondrial |
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| Ligand | BDBM118217 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ALDH2 Assay |
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| pH | 7.4±n/a |
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| IC50 | 43±n/a nM |
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| Comments | extracted |
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| Citation |  Graupe, M; Venkataramani, C; Zablocki, J ALDH-2 inhibitors in the treatment of addiction US Patent US8673966 Publication Date 3/18/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldehyde dehydrogenase, mitochondrial |
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| Name: | Aldehyde dehydrogenase, mitochondrial |
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| Synonyms: | ALDH class 2 | ALDH-E2 | ALDH2 | ALDH2_HUMAN | ALDHI | ALDM | Aldehyde dehydrogenase (ALDH2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56382.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05091 |
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| Residue: | 517 |
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| Sequence: | MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
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| BDBM118217 |
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| n/a |
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| Name | BDBM118217 |
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| Synonyms: | US8673966, N-(4-(4-oxo-7-((tetrahydro-2H-pyran-4- yl)ethynyl)-4H-chromen-3-yl)phenyl)methanesulfonamide |
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| Type | n/a |
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| Emp. Form. | C23H21NO5S |
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| Mol. Mass. | 423.482 |
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| SMILES | CS(=O)(=O)Nc1ccc(cc1)-c1coc2cc(ccc2c1=O)C#CC1CCOCC1 |
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| Structure | 
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