| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] B |
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| Ligand | BDBM118220 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MAO-A and MAO-B Assays |
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| pH | 7.5±n/a |
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| IC50 | >130000±n/a nM |
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| Comments | extracted |
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| Citation |  Graupe, M; Venkataramani, C; Zablocki, J ALDH-2 inhibitors in the treatment of addiction US Patent US8673966 Publication Date 3/18/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Amine oxidase [flavin-containing] B |
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| Name: | Amine oxidase [flavin-containing] B |
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| Synonyms: | AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB) |
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| Type: | Protein |
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| Mol. Mass.: | 58768.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27338 |
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| Residue: | 520 |
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| Sequence: | MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
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| BDBM118220 |
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| n/a |
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| Name | BDBM118220 |
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| Synonyms: | US8673966, N-(4-(7-((1-(3,3-difluorocyclobutanecarbonyl)- azetidin-3-yl)ethynyl)-4-oxo-4H-chromen-3-yl)phenyl)methanesulfonamide |
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| Type | n/a |
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| Emp. Form. | C26H22F2N2O5S |
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| Mol. Mass. | 512.525 |
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| SMILES | CS(=O)(=O)Nc1ccc(cc1)-c1coc2cc(ccc2c1=O)C#CC1CN(C1)C(=O)C1CC(F)(F)C1 |
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| Structure | 
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