| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
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| Ligand | BDBM119091 |
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| Substrate/Competitor | n/a |
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| Ki | 3.4e+3±n/a nM |
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| Citation |  Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem55:2-15 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
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| Name: | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
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| Synonyms: | EPT | Enoylpyruvate transferase | MURA_ECOLI | MurA (E. coli) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA | murZ |
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| Type: | Protein |
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| Mol. Mass.: | 44814.62 |
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| Organism: | Escherichia coli K-12 (Enterobacteria) |
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| Description: | E. coli MurA |
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| Residue: | 419 |
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| Sequence: | MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQL
GAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGAR
PVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTT
IIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLV
AAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHP
AFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKL
SGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
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| BDBM119091 |
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| n/a |
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| Name | BDBM119091 |
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| Synonyms: | Feglymicin (compound 30) |
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| Type | Small organic molecule |
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| Emp. Form. | C95H97N13O30 |
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| Mol. Mass. | 1900.8558 |
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| SMILES | CC(C)[C@H](NC(=O)[C@H](NC(=O)[C@H](N)c1ccc(O)cc1)c1cc(O)cc(O)c1)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(O)=O)c1ccc(O)cc1)c1cc(O)cc(O)c1)c1cc(O)cc(O)c1)c1ccc(O)cc1)c1cc(O)cc(O)c1)c1ccc(O)cc1)c1cc(O)cc(O)c1 |r| |
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| Structure | 
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