| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Ligand | BDBM119097 |
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| Substrate/Competitor | n/a |
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| IC50 | <1±0.0 nM |
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| Citation |  Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem55:2-15 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Name: | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Synonyms: | D-glutamic acid-adding enzyme | MURD_ECOLI | MurD (E. coli) | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | murD |
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| Type: | Ligase |
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| Mol. Mass.: | 46963.02 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | n/a |
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| Residue: | 438 |
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| Sequence: | MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLND
EWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVT
TLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNV
TEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHL
NHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGL
PHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYL
NGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQF
KNFEQRGNEFARLAKELG
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| BDBM119097 |
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| n/a |
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| Name | BDBM119097 |
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| Synonyms: | MurD inhibitor (compound 36) |
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| Type | Small organic molecule |
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| Emp. Form. | C28H45N4O24P3 |
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| Mol. Mass. | 914.5906 |
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| SMILES | C[C@@H](O[C@H]1[C@H](O)[C@@H](CO)OC(OP(O)(=O)OP(O)(=O)OCC2OC(C(O)C2O)n2ccc(=O)[nH]c2=O)[C@@H]1NC(C)=O)C(=O)N[C@H](C)P(O)(=O)CC(CCC(O)=O)C(O)=O |r| |
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| Structure | 
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