| Reaction Details |
|---|
 | Report a problem with these data |
| Target | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
|---|
| Ligand | BDBM85276 |
|---|
| Substrate/Competitor | n/a |
|---|
| IC50 | 1.8e+4±n/a nM |
|---|
| Citation |  Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem55:2-15 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| UDP-N-acetylmuramoylalanine--D-glutamate ligase |
|---|
| Name: | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
|---|
| Synonyms: | D-glutamic acid-adding enzyme | MURD_ECOLI | MurD (E. coli) | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | murD |
|---|
| Type: | Ligase |
|---|
| Mol. Mass.: | 46963.02 |
|---|
| Organism: | Escherichia coli (strain K12) |
|---|
| Description: | n/a |
|---|
| Residue: | 438 |
|---|
| Sequence: | MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLND
EWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVT
TLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNV
TEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHL
NHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGL
PHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYL
NGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQF
KNFEQRGNEFARLAKELG
|
|
|
|---|
| BDBM85276 |
|---|
| n/a |
|---|
| Name | BDBM85276 |
|---|
| Synonyms: | HEA derivative, 7c | MurC/D/E/F inhibitor (compound 68) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H20F3N2O7PS |
|---|
| Mol. Mass. | 448.352 |
|---|
| SMILES | OP(O)(=O)OC(CNS(=O)(=O)c1ccc(cc1)C(F)(F)F)CN1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
