| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase |
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| Ligand | BDBM85276 |
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| Substrate/Competitor | n/a |
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| IC50 | 2.40e+5±n/a nM |
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| Citation |  Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem55:2-15 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase |
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| Name: | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase |
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| Synonyms: | MURF_ECOLI | MurF (E. coli) | mra | murF |
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| Type: | Protein |
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| Mol. Mass.: | 47439.03 |
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| Organism: | Escherichia coli |
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| Description: | P11880 |
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| Residue: | 452 |
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| Sequence: | MISVTLSQLTDILNGELQGADITLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAG
GAGALLVSRPLDIDLPQLIVKDTRLAFGELAAWVRQQVPARVVALTGSSGKTSVKEMTAA
ILSQCGNTLYTAGNLNNDIGVPMTLLRLTPEYDYAVIELGANHQGEIAWTVSLTRPEAAL
VNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRKVWRFS
PNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMSVGATL
DAIKAGLANLKAVPGRLFPIQLAENQLLLDDSYNANVGSMTAAVQVLAEMPGYRVLVVGD
MAELGAESEACHVQVGEAAKAAGIDRVLSVGKQSHAISTASGVGEHFADKTALITRLKLL
IAEQQVITILVKGSRSAAMEEVVRALQENGTC
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| BDBM85276 |
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| n/a |
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| Name | BDBM85276 |
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| Synonyms: | HEA derivative, 7c | MurC/D/E/F inhibitor (compound 68) |
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| Type | Small organic molecule |
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| Emp. Form. | C14H20F3N2O7PS |
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| Mol. Mass. | 448.352 |
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| SMILES | OP(O)(=O)OC(CNS(=O)(=O)c1ccc(cc1)C(F)(F)F)CN1CCOCC1 |
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| Structure | 
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