| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysosomal Pro-X carboxypeptidase |
|---|
| Ligand | BDBM50443343 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Activity Assay |
|---|
| IC50 | 17±n/a nM |
|---|
| Citation |  Shen, D; Debenham, JS; Graham, TH; Clements, MJ; Zhang, Y Prolylcarboxypeptidase inhibitors US Patent US8669252 Publication Date 3/11/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysosomal Pro-X carboxypeptidase |
|---|
| Name: | Lysosomal Pro-X carboxypeptidase |
|---|
| Synonyms: | Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55805.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P42785 |
|---|
| Residue: | 496 |
|---|
| Sequence: | MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHF
GFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFA
EHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSY
GGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRS
WDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQP
LPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWS
YQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHT
NIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRH
MKNWIRDFYDSAGKQH
|
|
|
|---|
| BDBM50443343 |
|---|
| n/a |
|---|
| Name | BDBM50443343 |
|---|
| Synonyms: | CHEMBL3086028 | US8669252, 56 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H36BrF2N3O2 |
|---|
| Mol. Mass. | 612.548 |
|---|
| SMILES | CCN(CC)CC(=O)N[C@@H]1CC[C@H]([C@@H](C1)c1ccc(Br)cc1)C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
