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TargetEnoyl-acyl carrier reductase ENR
LigandBDBM50174774
Substrate/Competitorn/a
Meas. Tech.TgENR Inhibition Assay
pH7.5±n/a
IC50 16±0.0 nM
Commentsextracted
Citation Afanador, GA; Muench, SP; McPhillie, M; Fomovska, A; Schön, A; Schön, Y; Cheng, G; Stec, J; Freundlich, JS; Shieh, HM; Anderson, JW; Jacobus, DP; Fidock, DA; Kozikowski, AP; Fishwick, CW; Rice, DW; Freire, E; McLeod, R; Prigge, ST Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay. Biochemistry52:9155-66 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Enoyl-acyl carrier reductase ENR
Name:Enoyl-acyl carrier reductase ENR
Synonyms:Enoyl-acyl carrier reductase | Enoyl-acyl carrier reductase (ENR) | Enoyl-acyl carrier reductase, putative
Type:PROTEIN
Mol. Mass.:43663.67
Organism:Toxoplasma gondii
Description:ChEMBL_1290812
Residue:417
Sequence:
MVGFKLLTLGAFVAGELTLVGPAGTMAFTVPNATGAKPLVTSVSVRPSWSSARQNAFSSS
SSRSQSSVRPHSAFVTNRLETAGETGTQHRAADSAAGVGAAQSAFPIDLRGQTAFVAGVA
DSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRKLPDGSLIEFAGVYP
LDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDILVHSLANGPEVTKPL
LETSRKGYLAASSNSAYSFVSLLQHFGPIMNEGGSAVTLSYLAAERVVPGYGGGMSSAKA
ALESDTRTLAWEAGQKYGVRVNAISAGPLKSRAASAIGKSGEKSFIDYAIDYSYNNAPLR
RDLHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHAMGQAVDSRSMPPLQRATQEIN
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  Blast E-value cutoff:
BDBM50174774
n/a
NameBDBM50174774
Synonyms:2‐({[3‐chloro‐4‐(4‐chloro‐2‐ hydroxyphenoxy)phenyl]amino}methyl)benzonitrile (10) | 2-((3-chloro-4-(4-chloro-2-hydroxyphenoxy)phenylamino)methyl)benzonitrile | CHEMBL200492
TypeSmall organic molecule
Emp. Form.C20H14Cl2N2O2
Mol. Mass.385.243
SMILESOc1cc(Cl)ccc1Oc1ccc(NCc2ccccc2C#N)cc1Cl
Structure
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