| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxypeptidase B |
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| Ligand | BDBM120788 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 12±n/a nM |
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| Comments | extracted |
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| Citation |  Kallus, C; Heitsch, H; Lindenschmidt, A; Grueneberg, S; Szillat, H Imidazole derivatives used as TAFIa inhibitors US Patent US8710232 Publication Date 4/29/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Carboxypeptidase B |
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| Name: | Carboxypeptidase B |
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| Synonyms: | CBPB1_HUMAN | CPB | CPB1 | Carboxypeptidase B | PASP | PCPB | Pancreas-specific protein | Thrombin-activatable fibrinolysis (TAFI) |
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| Type: | Enzyme |
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| Mol. Mass.: | 47367.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15086 |
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| Residue: | 417 |
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| Sequence: | MLALLVLVTVALASAHHGGEHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQ
IKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEKYN
KWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREW
ISPAFCQWFVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTH
TGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAY
LTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAG
GSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASYVLEHLY
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| BDBM120788 |
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| n/a |
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| Name | BDBM120788 |
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| Synonyms: | US8710232, 15 |
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| Type | n/a |
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| Emp. Form. | C24H27N5O3 |
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| Mol. Mass. | 433.5029 |
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| SMILES | Nc1ccc(CC(C(O)=O)c2cn(CC3CCCCN3C(=O)c3ccccc3)cn2)cn1 |
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| Structure | 
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