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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Hepatocyte growth factor receptor | ||
| Ligand | BDBM120819 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | HTRF kinase assay | ||
| pH | 7±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 8.78±0.0 nM | ||
| Comments | extracted | ||
| Citation |  Zhou, S; Ren, J; Liu, M; Ren, L; Liu, Y; Gong, P Design, synthesis and pharmacological evaluation of 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agents. Bioorg Chem57:30-42 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Hepatocyte growth factor receptor | |||
| Name: | Hepatocyte growth factor receptor | ||
| Synonyms: | Hepatocyte growth factor receptor | Hepatocyte growth factor receptor (MET) | Hepatocyte growth factor receptor (c-MET) | Hepatocyte growth factor receptor (cMET) | MET | MET_HUMAN | Met proto-oncogene (hepatocyte growth factor receptor) | Proto-oncogene c-Met | Tyrosine-protein kinase Met (c-Met) | Tyrosine-protein kinase Met (cMet) | c-Met kinase | ||
| Type: | Protein | ||
| Mol. Mass.: | 155559.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08581 | ||
| Residue: | 1390 | ||
| Sequence: |
| ||
| BDBM120819 | |||
| n/a | |||
| Name | BDBM120819 | ||
| Synonyms: | (E)-5-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopropoxy) quinolin-4-yl)oxy)phenyl)amino)m ethylene)-3-(2-fluorophenyl)-1- methylimidazolidine-2,4-dione (40) | ||
| Type | Small organic molecule | ||
| Emp. Form. | C34H33F2N5O6 | ||
| Mol. Mass. | 645.6525 | ||
| SMILES | COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4F)c(=O)n3C)ccnc2cc1OCCCN1CCOCC1 |w:14.14,(-7.96,1.65,;-6.63,2.42,;-5.29,1.65,;-3.96,2.42,;-2.63,1.65,;-1.29,2.42,;-1.29,3.96,;.04,4.73,;1.37,3.96,;2.71,4.73,;2.71,6.27,;1.37,7.04,;.04,6.27,;-1.29,7.04,;4.04,7.04,;5.38,6.27,;6.71,7.04,;6.87,8.57,;5.73,9.6,;8.38,8.89,;9,10.3,;10.53,10.46,;11.16,11.87,;10.26,13.11,;8.72,12.95,;8.1,11.54,;6.57,11.38,;9.15,7.56,;10.68,7.4,;8.12,6.41,;8.44,4.91,;.04,1.65,;.04,.11,;-1.29,-.66,;-2.63,.11,;-3.96,-.66,;-5.29,.11,;-6.63,-.66,;-7.96,.11,;-9.29,-.66,;-10.63,.11,;-11.96,-.66,;-13.3,.11,;-14.63,-.66,;-14.63,-2.2,;-13.3,-2.97,;-11.96,-2.2,)| | ||
| Structure | 
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